2025Endocrinol Metab Clin
Yoon J et al
“Cross-sectional study of mitochondrial-derived peptide levels against metabolic biomarkers. Correlative; not causal.”
↳ Topics · 2 papers · 1 editorial
Metabolic pathway research.
Mitochondrial multitaskers, AMPK signalling, and the gap between published mechanism research and the consumer-marketing narrative.
§ About this topic
Metabolic-pathway research focuses on mitochondrial-derived peptides — small signalling molecules encoded by mitochondrial DNA — and their effect on cross-tissue metabolic state. The mechanism literature is interesting and reasonably documented: AMPK activation, mitochondrial biogenesis, fat-oxidation rates, exercise-mimetic adaptations. The consumer-marketing translation (weight loss, exercise replacement) outruns the evidence; this cluster stays at the mechanism level.
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2023Cell Metab
Zheng Y et al
“Reviews evidence for mitochondrial-derived peptides as exercise-mimetic candidates. Mixed signals across studies; no consensus on outcome equivalence.”
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