2024Cureus
Cushman DM, Holman A, Bouvette S, McCormick ZL
“Narrative review of regenerative peptide signalling in soft-tissue and joint pathologies. Predominantly preclinical evidence base; human evidence is limited to case series.”
↳ Topics · 2 papers · 1 editorial
Regenerative-peptide pathway.
How short signalling peptides accelerate the body's own tissue-repair machinery — wound closure, tendon healing, gut barrier integrity, vascular regrowth.
§ About this topic
Regenerative-peptide research focuses on short signalling molecules that engage the cell's repair pathways: VEGF up-regulation for new blood vessels, fibroblast-mediated collagen deposition for wound closure, anti-inflammatory cascades for soft-tissue recovery. Most of the published evidence is preclinical (rodent and in-vitro), with a smaller but growing human case-series literature in orthopaedic and gastrointestinal contexts. The mechanism is mature; the human-outcome evidence still has gaps.
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2025Bone Joint J Open
Vasireddi N, Vasireddi N, Shah AK, et al
“Reviews orthopaedic-context peptide signalling: VEGF, fibroblast collagen deposition, and inflammatory phase modulation in tendon and ligament repair models.”
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