Mechanism overviews · 29 papers
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Neuropeptide

Kisspeptin

Also known as: Kisspeptin-10 · Metastin

A hypothalamic peptide studied in reproductive-endocrinology and HPG-axis research.

Written by Peptidoteca Research Desk·Reviewed by Peptidoteca Research Desk·Last reviewed 2026-06-14·3 sources

§ In brief

Kisspeptin (also known as Kisspeptin-10, Metastin) is a hypothalamic peptide studied in reproductive-endocrinology and HPG-axis research. It is supplied for laboratory research use only and is not approved for human or veterinary use. Its 10-residue amino-acid sequence is YNWNSFGLRF.

What is Kisspeptin?

A hypothalamic peptide studied in reproductive-endocrinology and HPG-axis research.

Kisspeptin is catalogued here as a reference compound for neuropeptide and cognitive research. The entry covers its chemical identity and the public databases that describe it; it is not a usage guide.

How is Kisspeptin studied?

Kisspeptin appears in the neuropeptide and cognitive literature, primarily in in-vitro and preclinical (animal) models. This page indexes 3 primary papers on Kisspeptin, each tagged with its study type below. Peptidoteca summarizes the proposed mechanism class and the primary sources rather than human outcomes; for the wider library, see the research library.

Is Kisspeptin approved for human use?

No. Kisspeptin is supplied for laboratory (in-vitro) research use only. It is not approved by the FDA or any comparable regulator for human or veterinary use, and nothing on this page constitutes medical advice, dosing guidance or a treatment recommendation.

What are the research limitations?

Most available evidence for Kisspeptin is preclinical — in-vitro and animal models — and findings in those models do not establish efficacy or safety in humans. Human clinical data is limited or absent, and Kisspeptin is not an approved drug. Treat the literature as mechanistic research, not clinical guidance.

§ Primary literature

  1. 1.Wei Suocheng (2026). Kisspeptin-10 Promotes Hormone Secretion, Ovarian Follicles Development and Fecundity via PI3K/AKT/ERK Signal Pathway in Mice. Molecular Reproduction and Development.Rodent studyIn a mouse study including cultured ovarian granulosa cells, Kisspeptin-10 was associated with increased granulosa-cell proliferation, ovarian follicle development, and higher serum progesterone and estradiol, reportedly acting through the PI3K/AKT/ERK signaling pathway.
  2. 2.Szysiak N (2026). Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes. Journal of Veterinary Research.OtherIn ewe lambs tracked across the peripubertal period, plasma kisspeptin-10 and neurokinin B concentrations rose with age while dynorphin A declined; the onset of ovarian activity coincided with concurrent increases in kisspeptin-10 and neurokinin B alongside reduced dynorphin A.
  3. 3.Szysiak N (2025). Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes in vitro. Journal of Veterinary Research.In-vitroIn an in-vitro study of cultured anterior pituitary cells from pubescent ewes, neurokinin B was reported to increase kisspeptin-10 secretion in a dose- and time-dependent manner, whereas dynorphin A had no significant effect on its release.
Compound spec
Sequence
YNWNSFGLRF
Length10 aa
ClassNeuropeptide
CAS374675-21-5
Research vial10 mg

For in-vitro research only. Not medical, clinical or dosing advice.